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| Interactions: | Amphotericin B Adverse Effect: Enhanced hypokalemia
Clinical Management: Check serum potassium levels at frequent intervals; use potassium supplements if necessary
AspirinAdverse Effect: Increased ulcerogenic effect & decreased pharmacologic effect of Aspirin Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose Aspirin therapy. # Clinical Management: Monitor for the therapeutic effects and adjust the dose of salicylate if required.
Frusemide Adverse Effect: Enhanced hypokalemia
Clinical Management: Check serum potassium levels at frequent intervals; use potassium supplements if necessary.
NorethindroneAdverse Effect: Increased tendency towards developing edema
Clinical Management: Concomitant administration should be done with caution especially in patients with hepatic or cardiac disease.
OxymetholoneAdverse Effect: Increased tendency towards developing edema
Clinical Management: Concomitant administration should be done with caution especially in patients with hepatic or cardiac disease.
Phenobarbitone Adverse Effect: Increased metabolic clearance of Fludrocortisone acetate due to the induction of hepatic enzymes by Barbiturates
Clinical Management: Monitor for the possible diminished effect of Fludrocortisone acetate and increase the dosage accordingly
PhenytoinAdverse Effect: Increased metabolic clearance of Fludrocortisone acetate due to the induction of hepatic enzymes
Clinical Management: Monitor for the possible diminished effect of Fludrocortisone acetate and increase the dosage accordingly.
Rifampicin Adverse Effect: Increased metabolic clearance of Fludrocortisone acetate due to the induction of hepatic enzymes
Clinical Management: Monitor for the possible diminished effect of Fludrocortisone acetate and increase the dosage accordingly. |
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